U.C.L.A. Rheumatology Pathophysiology of Disease Course Lecture,
Second Year Medical School 1997

 
 
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Rheumatoid Arthritis     Page 14
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      damage. They are the predominant lymphocyte population in the proliferative synovium and they release cytokines which amplify and perpetuate inflammation in the joints and activate B cells (figure 5). They are believed to be activated through the RA-related MHC Class II epitope described above in combination with a disease-provoking antigenic peptide or with a super-antigen that binds to the MHC. The pathogenic sets of T cells are suspected to share certain common T cell receptors.

   
Figure 4. A closeup of the schematic drawing of HLA-DR4 in figure 3. Click thumbnail figure to view full graphic. 219 x 164 pixels 16kbs
 
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Figure 5. A scheme demonstrating the effects of T cell activation is depicted. Click thumbnail figure to view full graphic.. 219 x 164 pixels 10kbs
Click Picture or here for larger slide and further discussion (640 x 480) 44kb
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