U.C.L.A. Rheumatology Pathophysiology of Disease Course Lecture,
Second Year Medical School 1997

  
 
SLE Figure 5
Page 50
      Movie: Antigen is presented to a T cell and an intracellular signal is produced. 1.75 megs.
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Movie: The signal acts on the nucleus and new cytokines are produced and secreted. 1.7 megs.
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Antigen presentation with subsequent T-cell signaling: An intracellular signal is induced by interaction of the trimolecular complex.
T-cell activation leads to cytokine production : An intracellular signal ultimately impacts the cell nucleus leading to transcription, translation, and the formation of IL-1.

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Antigen presentation with subsequent T-cell signaling : An intracellular signal ultimately impacts the cell nucleus leading to transcription, and translation, and the formation of IL-1.
T-cell activation leads to cytokine production : The intracellular signal ultimately impacts the cell nucleus leading to transcription, translation, and the formation of IL-1.		  
Figure 5. A scheme demonstrating the effects of T cell activation is depicted. Antigen presentation to T cells is shown on the left. The small number of T cells that are capable of responding to antigen, by allowing a proper fit of the MHC-peptide complex with their TCR, produce a positive intracellular signal. This signal leads to activation of the T cells with resulting proliferation and differentiation. Ultimately, the T cells will impact a wide variety of cells types, generally through the production of a number of cytokines. In a normal immune response to an invading organism, this mechanism will result in a speedy removal of the offending agent. However, in autoimmune diseases such as RA, this weaponry is unleashed indiscriminately.. jpeg 320 x 240 pixels 6kbs
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Antigen presentation with subsequent T-cell signaling : An intracellular signal is induced by interaction of the trimolecular complex.
T-cell activation leads to cytokine production : The intracellular signal ultimately impacts the cell nucleus leading to transcription, translation, and the formation of IL-1.
 
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