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U.C.L.A. Rheumatology Pathophysiology of Disease Course Lecture, |
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Osteoporosis Page 27 |
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Risk factors for osteoporosis can be classified as 1. Constitutional/Genetics/Aging which include A. low bone mass, B. advanced age, C. being female, D. being Caucasian, E. having a family history, F. premature menopause (or a surgically induced menopause), G. thinness or weakness or weight loss. 2. Lifestyle and/or Nutritional which include A. smoking, B. heavy alcohol use, C. inactivity, D. calcium or vitamin D deficiency. 3. Medical Conditions or Drugs which include A. gastrectomy, B. hyperthyroidism (or thyroid replacement therapy), C. Cushing's disease (corticosteroids as therapy), and as a positive influence D. estrogens, E. thiazide diuretics.
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| Figure 4. The likelihood of fractures in a lifetime from 50 years of age is shown. jpeg 430 x 250 pixels 9kbs freehand 3dstudio max | |||||||||||||||||||
| The clinical presentation of osteoporosis is analogous to hypertension in that the process is clinically silent for many years or decades and then the clinical course is punctuated by a catastrophic event. In the case of osteoporosis, these events consist of fractures of bones. The likelihood of fractures occuring in a lifetime from 50 years of age is shown in figure 4. Vertebral insufficiency fractures are the most common fractures which occur as a result of osteoporosis, and result in the characteristic deformity of osteoporosis, the so called dowager's hump (figure 5). | |||||||||||||||||||
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