U.C.L.A. Rheumatology Pathophysiology of Disease Course Lecture,
Second Year Medical School 1997

  
 
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Osteoporosis    Page 26
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       Postmenopausal (Type 1) osteoporosis results from a loss of ovarian function. The absence of the affects of estrogen on bone leads to both an increase in bone formation and resorption. However, the resorption of bone is relatively more affected and therefore bone loss ensues. Since the turnover of trabecular bone is far greater than cortical bone, trabecular bone is more significantly affected by this process. Rapid bone mass loss occurs in women over the five years following menopause (figure 3).

       Aging associated (Type 2) osteoporosis is a result of a decrease of the amount of bone formed with each cycle over time. It appears that there is a general loss of osteoblasts with aging which more significantly impacts the formation of cortical bone.

   
Figure 3. This graph demonstrates the rapid bone loss experienced by women after menopause. j peg 460 x 340 pixels 15kbs freehand 3dstudio max
 
   
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