Pathophysiology of Spondyloarthropathies: Theory #8 HLA-B27 Has a Significantly Slower Rate of Molecular Folding Than Other HLA Class I Molecules and it May Misfold, Resulting in an Endoplasmic Reticulum Overloading Responsees Page 58
Windows Media Player
QuickTime Media Player
Real Media Player
The effects on the er of a misfolded HLA-B27 molecules is shown.
HLA-B27 has a significantly slower rate of folding than products of other HLA alleles and it may misfold. A misfolded protein is shown here returning to the cytosol. When misfolded proteins accumulate in the ER, an ER "unfolded protein response" occurs and leads to an ER "overloading response", which can result in release of calcium from the ER (as shown here) and other stress responses. The end result is that NF-KB is released from its cytosolic inhibitor I-KB, and NF-KB is able to enter the nucleus and bind to DNA, where it regulates gene transcription. Pro-inflammatory cytokines are then produced. Could this response be the cause of autoimmunity in Spa's?
Slide 4: "HLA-B27 Returns from the Endoplasmic Reticulum (ER) to the Cytosol: view #2" 360 x 240 pixels 22kb drawn freehand in 3dStudio Max.
Slide 5: "ER Stress Leads to Calcium Release, as depicted " 360 x 240 pixels 38kb drawn freehand in 3dStudio Max.
Slide 6: "The Increased Calcium Concentration leads to the Release of NF-KB from its cytosolic inhibitor, I-KB" 360 x 240 pixels 15kb drawn freehand in 3dStudio Max.
Slide 7: "NF-KB is able to enter the nucleus and bind to DNA, where it regulates gene transcription." 360 x 240 pixels 15kb drawn freehand in 3dStudio Max..
Slide 8: "NF-KB's Impact on the Nucleus Ultimately results in a Pro-Inflammatory Response by the Cell "360 x 240 pixels 18kb drawn freehand in 3dStudio Max.
Slide 9: "Could this response be the cause of autoimmunity in the Spondyloarthropathies?" 360 x 240 pixels 21kb drawn freehand in 3dStudio Max.
......Index 
Go to Previous page .....Go to Next page
