Pathophysiology of Spondyloarthropathies: Theory #7 HLA-B27 Directly Modifies Early Cell Signaling Events Leading to Alterations in Resulting Nuclear Factors Page 57
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The HLA-B27 on cells is shown modifying early cell signaling.
Slide 1: "An Experiment is shown in which there are Two types of HeLa Cells Present; Cells with HLA-B27 on their surface, and Cells with a different HLA Class I Protein Displayed " 360 x 240 pixels 14kb drawn freehand in 3dStudio Max
Slide 2: "Chlamydia Bacteria are Incubated with the HeLa Cells, as drawn here " 360 x 240 pixels 13kb drawn freehand in 3dStudio Max.
Slide 3: "The Incubation of the Bacterium Chlamydia with these cells Results in Different Types of Intracellular Signaling in each cell, as Reflected by the Different Colors representing the Signals " 360 x 240 pixels 14kb drawn freehand in 3dStudio Max.
HLA-B27 could directly modify early events such as cell signaling which can occur within seconds after a bacterium encounters a cell. Such an experiment is illustrated here with different effects on intracellular signaling represented by different colors. When bacteria are incubated with HeLa cells, HLA-B27 positive cells, but not cells with different HLA-B alleles, rapidly activated c-fos, AP-1, and MCP-1.
Slide 4: "Nuclear Factors associated with Cell Activation are Generated in the HLA-B27 Positive Cells, but not in the Cells Displaying a Different MHC Class I Protein" 360 x 240 pixels 14kb drawn freehand in 3dStudio Max.
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