U.C.L.A. Rheumatology Pathophysiology of Disease Course Lecture, Second Year Medical School 2005
 
 
 
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Pathophysiology of Spondyloarthropathies: Theory #5 The Heavy Chain Theory; HLA-B27 Heavy Chain Forms Stable Dimers    Page 55   

  
 
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The possible contribution to SpA pathogenesis by free HLA-B27 heavy chain is described.
Animation: SpA Pathophysiology #5: The possible contribution to SpA pathogenesis by free HLA-B27 heavy chain is described.
Animation: SpA Pathophysiology #5: The possible contribution to SpA pathogenesis by free HLA-B27 heavy chain is described.
Animation: SpA Pathophysiology #5: The possible contribution to SpA pathogenesis by free HLA-B27 heavy chain is described.
 
       
Slide 1: "The Intact HLA-B27 Molecule is shown " 360 x 240 pixels 13kb drawn freehand in 3dStudio Max Slide 2: "HLA-B27 Free Heavy Chain (without b2-microglobulin) is drawn inserted into the Cell Membrane " 360 x 240 pixels 9kb drawn freehand in 3dStudio Max.
Slide 3: "HLA-B27 Free Heavy Chain is drawn; the location of a free Cysteine at residue 67 is depicted " 360 x 240 pixels 11kb drawn freehand in 3dStudio Max.
Click Picture or here for larger slides (720 x 480 ) 47kb
Click Picture or here for larger slides (720 x 480 ) 52kb Click Picture or here for larger slides (720 x 480 ) 49kb
             Mice that express the human HLA-B27 heavy chain transgene, but with the b2-microglobulin gene deleted, develop arthritis. Free heavy chain has also been detected on human patients with AS, and is shown.
             HLA-B27 is different from most HLA-B alleles in having a free cysteine at residue 67, and HLA-B27 can form stable dimers without the presence of b2-microglobulin. One hypothetical dimer is depicted. It has been postulated that such a molecule would have a unique motif for the peptides it binds. The presence of such findings radically alters the classical views of pathogenesis.
 
     
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Slide 4: "A Hypothetical HLA-B27 Heavy Chain Dimer is depicted. " 360 x 240 pixels 15kb drawn freehand in 3dStudio Max.
Click Picture or here for larger slides (720 x480 ) 29kb
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