U.C.L.A. Rheumatology Pathophysiology of Disease Course Lecture, Second Year Medical School 2005
 
 
 
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Pathophysiology of Spondyloarthropathies: Theory #4 The Complementarity Determining Region 3 (CD3) of the TCR and an Immunodominant Antigen    Page 54
 
 
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T he possibility of the role of an immunodominant antigen is explored by examining Spatial Relationship between the TCR CD3 alpha and beta chains and the mhc peptide complex.
Animation: SpA Pathophysiology #4: The possibility of the role of an immunodominant antigen is explored by examining Spatial Relationship between the TCR CD3 alpha and beta chains and the mhc peptide complex.
Animation: SpA Pathophysiology #4 :The possibility of the role of an immunodominant antigen is explored by examining Spatial Relationship between the TCR CD3 alpha and beta chains and the mhc peptide complex.
Animation: SpA Pathophysiology #4: The possibility of the role of an immunodominant antigen is explored by examining Spatial Relationship between the TCR CD3 alpha and beta chains and the mhc peptide complex.
 
       
Slide 1: "The Spatial Relationship between the TCR CD3 alpha and beta chains to the MHC/peptide complex is illustrated: view #1 " 360 x 240 pixels 16kb drawn freehand in 3dStudio Max. Slide 2: "The Spatial Relationship between the TCR CD3 a and b chains to the MHC/peptide complex is illustrated: view #2" 360 x 240 pixels 19kb drawn freehand in 3dStudio Max. Slide 3: "The Spatial Relationship between the TCR CD3 a and b chains to the MHC/peptide complex is illustrated: view #3" 360 x 240 pixels 17kb drawn freehand in 3dStudio Max.
Click Picture or here for larger slides (720 x 480 ) 47kb Click Picture or here for larger slides (720 x 480 ) 52kb Click Picture or here for larger slides (720 x 480 ) 49kb
            The complementarity determining region 3 (CD3) of the TCR alpha and beta chains straddle the central part of the peptide within the HLA-B27 groove, as shown. If there is an arthritis related immunodominant antigen contained in the joint, then it could be inferred that these regions would be conserved. Such a hypothesis is testable.
             In the second diagram, the contact of the CD3's with the peptide HLA-B27 molecule is illustrated, from the perspective of an approaching TCR. The regions on contact drawn extending out from the peptide are exaggerated somewhat for effect.
 
   
 
Slide 4: "The Spatial Relationship between the TCR CD3 a and b chains to the MHC/peptide complex is illustrated: view #4" 360 x 240 pixels 17kb drawn freehand in 3dStudio Max. Slide 5: " The contact of the CD3's with the Peptide HLA-B27 molecule is illustrated" 360 x 240 pixels 17kb drawn freehand in 3dStudio Max.
Click Picture or here for larger slides (720 x480 ) 29kb Click Picture or here for larger slides (800 x 600 ) 50kb
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