U.C.L.A. Rheumatology Pathophysiology of Disease Course Lecture, Second Year Medical School 2005
 
 
 
      Page 53
 
......Index Go to Previous page .....Go to Next page
 
 

Pathophysiology of Spondyloarthropathies: Theories #3 Cytotoxic T-Cells in the Joint, Bacterial Derived Peptide, Endogenous Peptides, and HLA-B27   Page 53

 
 
Windows Media Player
QuickTime Media Player
Real Media Player
  

Cytotoxic T-cells are shown in the joint killing both cells that are infected and those with just endogenous proteins.
Animation: SpA Pathophysiology #3: Cytotoxic T-cells are shown in the joint killing both cells that are infected and those with just endogenous proteins.
Animation: SpA Pathophysiology #3: Cytotoxic T-cells are shown in the joint killing both cells that are infected and those with just endogenous proteins.
Animation: SpA Pathophtysiology #3 : Cytotoxic T-cells are shown in the joint killing both cells that are infected and those with just endogenous proteins.
 
       
Slide 1: "Cloned Armed CTL, which recognize HLA-B27, are drawn within a Joint" 360 x 240 pixels 19kb drawn freehand in 3dStudio Max. Slide 2: "The CTL TCR recognize Both Target Cells HLA-B27/Peptide Complex: One Target cell has no Bacterial Antigens Present with the Cell " 360 x 240 pixels 19kb drawn freehand in 3dStudio Max. Slide 3: "Activation of the T-Cell via its TCR/CD8 Receptors, and Subsequent T-Cell Signaling Leads to preformed Granule release, as shown: " 360 x 240 pixels 14kb drawn freehand in 3dStudio Max.
Click Picture or here for larger slides (720 x 480 ) 47kb Click Picture or here for larger slides (720 x 480 ) 45kb Click Picture or here for larger slides (720 x 480 ) 31kb
       Shown here are CD8 positive CTL within a joint that recognize HLA-B27 both in the context of bacteria infected target cells with bacterial derived peptide, as well as simply HLA-B27 positive target cells with only endogenous peptides.
       The CTL method of killing is illustrated. Specific recognition of a peptide MHC complex on a target cell by a CTL results in T cell signaling, which leads to release of preformed granules by the cell onto the target cell. Death by apoptosis ensues.
 
   
 
    Page 53
 
Slide 4: "Death by Apoptosis Ensues " 360 x 240 pixels 11kb drawn freehand in 3dStudio Max.
......Index Go to Previous page .....Go to Next page
Click Picture or here for larger slides (720 x480 ) 29kb
 
About Us | Contact Us | ©2005 This web site has been developed and maintained by Craig W. Wiesenhutter, M.D.