Slide 1: "Mechanism of disease of Spondyloarthropathies (Spa)" 360 x 240 pixels 23kb drawn freehand in 3dStudio Max.
Slide 2: "The Theory of Molecular Mimicry illustrated #1: Chlamydia and a MHC Class I Protein are shown " 360 x 240 pixels 15kb drawn freehand in 3dStudio Max.
Slide 3: "The Theory of Molecular Mimicry illustrated #2: a Cross-Reacting Antibody Approaches " 360 x 240 pixels 14kb drawn freehand in 3dStudio Max.
For nearly three decades one major focus of research in the mechanism of disease of spondyloarthropathies (Spa) has been that native cell-surface antigens in the joint might cross-react, i.e. mimic surface epitopes of infecting bacteria, resulting in an autoimmune response.
Shown here is an example of molecular mimicry, in which humoral response is made to an epitope on both Chlamydia and the HLA-B27 heavy chain. The possibility of cell mediated reactions has also been investigated. A similar concept is that of arthritogenic peptides, depicted here. Ankylosing Spondylitis (AS) associated HLA-B27 subtypes, such as 2704, would be able to bind the peptide, whereas subtypes unassociated with AS would not. The bound peptide and HLA-B27 would then cause auto reactivity, a testable hypothesis. Also, the motifs allowing for selective binding can be studied, and as shown here, peptides containing the residue tyrosine at the C terminus are bound by the AS causing, but not by the AS sparing subtype.
Slide 4: "The Theory of Molecular Mimicry illustrated #3: Two Identical Antibodies bind with epitopes on Chlamydia and a HLA-B27 Molecule " 360 x 240 pixels 16kb drawn freehand in 3dStudio Max..
Slide 5: "The Arthritogenic Peptide Theory #1: an Arthritogenic Peptide and two subtypes of HLA-B27 are shown " 360 x 240 pixels 15kb drawn freehand in 3dStudio Max.
Slide 6: "The Arthritogenic Peptide Theory #2: The AS sparing HLA-B27 subtype 2706 is drawn " 360 x 240 pixels 15kb drawn freehand in 3dStudio Max.
Slide 7: "The Arthritogenic Peptide Theory #3: The peptide is unable to bind to the AS sparing HLA-B27 " 360 x 240 pixels 16kb drawn freehand in 3dStudio Max.
Slide 8: "The Arthritogenic Peptide Theory #4: The peptide binds to the AS Associated HLA-B27 Subtype" 360 x 240 pixels 18kb drawn freehand in 3dStudio Max.
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