The Cytotoxic T-Cell Response, Dendritic Cells, Lymph Nodes, High Endothelial Venules (HEV), and T-Cell Activation Part I Page 50
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The production of cytotoxic T-cells is shown from dendritic cell activation to entry into the lymph node and initial contact with T-cells.
Animation: Cytotoxicity #1 : The production of cytotoxic T-cells is shown from dendritic cell activation to entry into the lymph node and initial contact with T-cells.
Animation: Cytotoxicity #1 : The production of cytotoxic T-cells is shown from dendritic cell activation to entry into the lymph node and initial contact with T-cells.
Animation: Cytotoxicity #1 : The production of cytotoxic T-cells is shown from dendritic cell activation to entry into the lymph node and initial contact with T-cells.
Slide 1: "An Activated Dendritic Cell is drawn Situated in the Inflammatory Focus " 360 x 240 pixels 19kb drawn freehand in 3dStudio Max.
Slide 2: "An Activated Dendritic Cell seen leaving the inflammatory site via a Lymphatic Vessel is shown " 360 x 240 pixels 22kb drawn freehand in 3dStudio Max.
Slide 3: "A Schematic Lymph Node is drawn #1 " 360 x 240 pixels 22kb drawn freehand in 3dStudio Max.
The dendritic cell has been influenced by the cytokines produced in the innate immune response as well as by contact with the organism. The cell becomes activated and matures. In addition to synthesizing co-stimulatory molecules and more MHC proteins, the cell is prompted to migrate from the submucosa, by way of the lymphatic vessel, to secondary lymph tissue, i.e. a lymph node.
At the lymph node, naive T cells arrive by high endothelial venules (HEV) and utilize their TCR to scan the antigen presenting cells. If the T cell does not recognize a peptide, then it leaves the lymph node via the efferent lymph vessel.
When a peptide MHC trimolecular complex is recognized by the TCR, and the appropriate co-stimulatory signals are also generated, the transduced signals will ultimately lead to T cell activation, proliferation, and maturation.
Slide 4: "A Schematic Lymph Node is drawn #2" 360 x 240 pixels 23kb drawn freehand in 3dStudio Max.
Slide 5: "The Activated Dendritic Cell arrives at the Lymph Node via an Afferent Lymphatic Vessel, as shown " 360 x 240 pixels 20kb drawn freehand in 3dStudio Max.
Slide 6: "A Schematic Lymph Node is drawn #3: Dendritic Cells are prepared to present Antigen " 360 x 240 pixels 25kb drawn freehand in 3dStudio Max
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