Translation of Membrane Bound Proteins such as MHC Class I Proteins, the Proteasome, Tapasin, and the TAP Complex Part I Page 48
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The translation of MHC class I protein starts at the cytosol ER border and is followed as it is folded and interacts with the TAP complex and then the molecule is further followed from the TAP complex until it has traveled to and is displayed on the cell surface.
Animation: Translation #2 : The translation of MHC class I protein starts at the cytosol ER border and is followed as it is folded and interacts with the TAP complex. Animation: Translation #3 : The molecule is further followed from the TAP complex until it has traveled and is displayed on the cell surface.
Animation: Translation #2 : The translation of MHC class I protein starts at the cytosol ER border and is followed as it is folded and interacts with the TAP complex. Animation: Translation #3 : The molecule is further followed from the TAP complex until it has traveled and is displayed on the cell surface.
Animation: Translation#2 : The translation of MHC class I protein starts at the cytosol ER border and is followed as it is folded and interacts with the TAP complex. Animation: Translation #3 : The molecule is further followed from the TAP complex until it has traveled and is displayed on the cell surface.
Slide 1: "The Initiation of Translation of a Membrane Bound Protein is drawn: with several important participants illustrated including Signal Recognition Particle (SRP), and the Rough Endoplasmic Reticulum #1 " 360 x 240 pixels24kb drawn freehand in 3dStudio Max.
Slide 2: "The Initiation of Translation of a Membrane Bound Protein is drawn: with additional important participants illustrated including the Ribosome, mRNA, Signal Peptide, and SRP Receptor Protein #2" 360 x 240 pixels 22kb drawn freehand in 3dStudio Max.
Slide 3: "The Peptide Extends from the Ribosome through the Translocation Complex " 360 x 240 pixels 20kb drawn freehand in 3dStudio Max.
MHC Class I proteins are membrane bound proteins. This animation depicts the production of such a protein at the junction between the rough endoplasmic reticulum and the cytosol. The critical folding of the protein into its secondary, tertiary and quaternary structure is aided by chaperone proteins.
Slide 4: "Critical Folding of the Protein into its secondary, tertiary and quaternary structure is aided by Chaperone Proteins. " 360 x 240 pixels 22kb drawn freehand in 3dStudio Max.
Slide 5: "The Chaperone Proteins, Calnexin and ERP57, are drawn " 360 x 240 pixels 22kb drawn freehand in 3dStudio Max.
Slide 6: "Calreticulin contributes further to the MHC Class I Protein Folding " 360 x 240 pixels 27kb drawn freehand in 3dStudio Max
Peptides to be presented at the cell surface are produced from polypeptides by the proteasome in the cytosol and enter the ER by way of the TAP complex, and then, if it fits, one of the peptides is loaded into the MHC Class I heavy chain groove. Tapasin acts as a bridge between peptides entering at the TAP and the MHC groove. The MHC Class I molecule makes its way to the membrane surface via a vesicle. The carbohydrate maturates in the Golgi apparatus. The MHC Class I protein at the end of the animation is shown as a ribbon structure, revealing its secondary structure of alpha helix and beta pleated sheets.
Slide 7: "Peptides enter from the Cytosol into the ER through the TAP Complex, as illustrated, with the aid of the Enzyme, Tapasin " 360 x 240 pixels 23kb drawn freehand in 3dStudio Max
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