U.C.L.A. Rheumatology Pathophysiology of Disease Course Lecture, Second Year Medical School 2005

 
 
 
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The B Cell and Rheumatoid Arthritis Part III: Antigen Presentation (Non-Self) by B-cells, T-cell Help and Helper Factors   Part III   Page 38    

 
 
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A B-cell making rheumatoid factors is shown, and a B-cell depleting agent is described.

Animation: The B-cell fools the T-cell
: The mechanism by which an autoantibody producing B-cell fools a T-cell to obtain help is animated.

Animation: The B-cell fools the T-cell
: The mechanism by which an autoantibody producing B-cell fools a T-cell to obtain help is animated.

Animation: The B-cell fools the T-cell
: The mechanism by which an autoantibody producing B-cell fools a T-cell to obtain help is animated.
 
       
Slide 1: "The B-cell Receptor binds to the Fc portion of an IgG, which in turn, Binds non-self Antigen " 360 x 240 pixels 15kb drawn freehand in 3dStudio Max Slide 2: "The B-cell Presents Non-Self Antigen, via its MHC Class II protein, to a T-cell via the T-cell's TCR " 360 x 240 pixels 16kb drawn freehand in 3dStudio Max Slide 3: "The B-cell Activates the T-cell with Non-Self Antigen " 360 x 240 pixels 15kb drawn freehand in 3dStudio Max
Click Picture or here for larger slides (720 x 480 ) 34kb Click Picture or here for larger slides (720 x 480 ) 38kb Click Picture or here for larger slides (720 x 480 ) 17kb
       This B-cell is able to fool T-cells into providing the necessary T-cell help. The B-cell first binds to its antigen, the IgG molecule, which in turn is complexed to a non-self antigen. The non-self antigen is internalized, processed, and presented by the B-cell with MHC class II proteins to the T-cell via the T-cell receptor, in the presence of the appropriate accessory molecules, resulting in activation of the T-cell.
       The end result of this antigen presentation is production by the T-cell of the necessary helper factors (IL-4, IL-5, IF?). The B-cell lives on.
 
   
 
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Slide 4: "The T-cell is Fooled into Giving the B-cell the Necessary "Help" " 360 x 240 pixels 16kb drawn freehand in 3dStudio Max

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