U.C.L.A. Rheumatology Pathophysiology of Disease Course Lecture,
Second Year Medical School 1997
Frequently Asked Questions Page 73
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No pathogen has been identified which is commonly accepted as the cause of Ankylosing spondylitis. However, in a related arthritis, the reactive arthrititis, the disease can be induced by infections with certain gram negative facultative intracellular bacteria such as Salmonella, Shigella and Yersinia. This family of arthritis also share the common HLA class I allele of HLA-B27.
Figure 3. Schematic diagram of a class I MHC molecule
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