U.C.L.A. Rheumatology Pathophysiology of Disease Course Lecture,
Second Year Medical School 1997

 
 
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      has been described. The musculoskeletal symptoms of Reiter's Syndrome are different from those of AS. Axial symptoms are less severe and may only affect the sacroiliac joints, and sometimes only unilaterally. Peripheral arthritis is more intense and fingers and toes may be swollen. Unlike RA the pathological process still appears centered in the capsules and ligamentous attachments rather than the synovium, resulting in "sausage-shaped" digits (figure 5).
       Reiter's Syndrome is also associated with conjunctivitis, urethritis, shallow ulcers on the tongue and palate, rashes on the palms and soles (keratoderma blenorrhagica) and a rash around the glans penis (circinate balanitis). These features are not seen in AS. The clinical differences between AS and Reiter's Syndrome may be the result of different infectious exposures in the same genetically susceptible host, or there may be subtle genetic and immunological differences between the two conditions which are as yet undetermined.
   
Figure 5. The short arrow shows the dactylitis of RS whereas the long arrow shows the fusiform swelling of a toe joint in a patient with RA. Click thumbnail figure to view full graphic. jpeg 219 x 164 pixels 17kbs freehand 3dstudio max
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