U.C.L.A. Rheumatology Pathophysiology of Disease Course Lecture, Second Year Medical School 2005
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Adenoviral (Adenovirus) and Chlamydial Infection, and a HLA-B27 Positive Patient, a Dendritic cell and a Macrophage Page 46
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The immune response to infection by the adenovirus in the lung, and chlamydia in the genitourinary system is animated.
Animation: Chlamydial Infection #1 : The immune response to infection by the adenovirus in the lung, and chlamydia in the genitourinary system is animated
Animation: Chlamydial Infection #2.
Animation: Chlamydial Infection #1 : The immune response to infection by the adenovirus in the lung, and chlamydia in the genitourinary system is animated.
Animation: Chlamydial Infection #2
Animation: Chlamydial Infection #1: The immune response to infection by the adenovirus in the lung, and chlamydia in the genitourinary system is animated.
Animation: Chlamydial Infection #2
Slide 2: "This is a Rendition of an EM showing the Hemispheric Projections of the elemental bodies" 360 x 240 pixels 51kb drawn freehand in 3dStudio Max.
Slide 3: "The good Doctor's Respiratory Tract Mucosa " 360 x 240 pixels 19kb drawn freehand in 3dStudio Max.
This is a rendition of an EM showing the hemispheric projections of the elemental bodies. Their purpose is not known.
This scene represents the initial immunologic battlefield, the sub mucosa of the Doctor's respiratory tract and Chubs' genitourinary tract. A macrophage is seen on patrol, while a dendritic cell awaits at its station, sampling extracellular materials for antigens by the means of macropinocytosis. A blood vessel and lymph vessel are shown.”.
can even induce phagocytosis in nonphagocytic cells. An Adenovirus is depicted initially adhering, through its fibers, to an adhesion molecule on the dendritic cell. The virus is internalized in endosomes and undergoes an uncoating.
The sub cellular structures that are important to the discussion are shown. The endomembrane system consists of the Golgi apparatus, and rough and smooth endoplasmic reticulum. The nucleus and nuclear pores are depicted. Note that the double layered outer membrane is continuous with the endomembrane system, and that the nuclear pores are continuous with the cytosol.
Once the Chlamydia enters the phagosomes of the cell, there is a morphologic change to the reticulate bodies (RB), as shown here. In this stage the organism is metabolically active and they divide, but they are quite fragile.
Lysosomes are inhibited from fusing with the phagosomes until just before host cell death.
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