Slide 1: "The Ribbon structure of a MHC Class I Protein is Viewed from the Front (front as a given) " 360 x 240 pixels 20kb drawn freehand in 3dStudio Max. Over 10 different images of MHC Class I Proteins were used to create this composition
Slide 2: "The Ribbon structure of a MHC Class I Protein is Viewed from the Side " 360 x 240 pixels 11kb drawn freehand in 3dStudio Max. Over 10 different images of MHC Class I Proteins were used to create this composition
Slide 3: "The Ribbon structure of a MHC Class I Protein is Viewed from the Back " 360 x 240 pixels 11kb drawn freehand in 3dStudio Max. Over 10 different images of MHC Class I Proteins were used to create this composition
Susceptibility to disease is strongly associated with the MHC class I protein, HLA-B27. Let us further examine the possible role of HLA-B27 in spondyloarthropathy.
The MHC, or major histocompatability complex, Class I protein is the star of the presentation and this book. Here its ribbon structure is shown demonstrating the heavy chain's (HC) alpha1, alpha2, alpha3 domains, as well as its transmembrane portion and cytoplasmic tail.
The beta2-microglobulin molecule associates with the HC noncovalently.
A close-up is made of the MHC groove, as seen by the viewpoint of an approaching T-Cell Receptor (TCR). The alpha helices and the beta-pleated sheets of the alpha1, and alpha2 domains are shown.
Peptides which are chemically complementary fit into the groove. A peptide backbone with eight residues is depicted. One characteristic of peptides that fit the HLA B27 motif is that they have an arginine at P2. The arginine anchors the peptide in the B pocket of HLA-B27. A peptide, now containing a space filling molecular model of the side chains of the residues, is shown. When the peptide enters the groove, the P1, P4 and P8 side chains are oriented upward and outward from the MHC groove, and these residues, along with a portion of the proteins comprising the a helices of the MHC, will interact with the TCR.
Slide 4: "The Ribbon structure of a MHC Class I Protein is Viewed from above #1(as viewing from the TCR) " 360 x 240 pixels 12kb Over 10 different images of MHC Class I Proteins were used to create this composition
Slide 5: "The Ribbon structure of a MHC Class I Protein is Viewed from above #2(as viewing from the TCR)" 360 x 240 pixels 26kb
Slide 6: "A Peptide which is Complementaric to the MHC Class I Pocket is shown: the Arginine Side chain is Evident " 360 x 240 pixels 44kb drawn freehand in 3dStudion Max
Slide 7: "A Peptide which is Complementaric to the MHC Class I Pocket: the Arginine Side chain is Evident: viewed from an angle " 360 x 240 pixels 19kb drawn freehand in 3dStudion Max
Slide 8: "A Peptide, which is Complementaric to the MHC Class I Protein, sits in the MHC's Groove: the Arginine Side chain Situated in the B Pocket Anchors the Molecule" 360 x 240 pixels 19kb drawn freehand in 3dStudion Max.
Slide 9: "The Amino Acid Side Chains of the Peptide are Included " 360 x 240 pixels 19kb drawn freehand in 3dStudion Max
Slide 10: "The Amino Acid Side Chains are Labeled" 360 x 240 pixels 16kb drawn freehand in 3dStudion Max
Slide 11: "The Molecular Structures of the MHC-Peptide Complex which Interact with the T-cell Receptor are Indicated " 360 x 240 pixels 15kb drawn freehand in 3dStudion Max
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