Author's note: this narration is repeated from the last page. Pyogenic bacteria are deposited and rapidly begin to multiply and spread. Fortunately for the good doctor, a macrophage cruising the tissue is present and able to intercede.The macrophage's scavenger receptor is capable of detecting multiple repeating chemical structures displayed by a variety of bacteria types. On contact, both the receptor and the bacteria are internalized, ultimately resulting in activation of the cell nucleus with subsequent new protein synthesis, and cytokine secretion, including the liberation of TNF, as shown here.
The cytokines in this setting serves as a call to arms to other inflammatory cells as well as an indicator to these cells as to the location of the infection.
Slide 10: "The Receptor and the Bacteria are Internalized, Ultimately Resulting in Activation of the Cell" 400 x 300 pixels 29kb drawn freehand in 3dStudio Max
Slide 11: "Cytokines, Including TNF, are Secreted #1 " 400 x 300 pixels 30kb drawn freehand in 3dStudio Max
The interaction of TNF with its trimeric receptor complex on a target cell, in this case an endothelial cell, is depicted and results in a conformational change in the receptor molecules as shown. This conformational change permits the attachment of a docking molecule, which then interacts an activates an enzyme resulting in an intracellular signal, nuclear activation, transcription and translation, and ultimately leading to the insertion of new adhesion molecules on the cell's surface.
Page 31
Slide 7: "A Splinter is about to Enter The Skin " 400 x 300 pixels 28kb drawn freehand in 3dStudio Max
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