U.C.L.A. Rheumatology Pathophysiology of Disease Course Lecture, Second Year Medical School 2005

 
   
 
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Hyaline Cartilage and the Chondrocyte  Page 10
 
 
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Formation of collagen fibers from collagen monomers is shown.

Animation: Cartilage and the Chondrocyte
: Formation of collagen fibers from collagen monomers is shown.

Animation: Cartilage and the Chondrocyte
: Formation of collagen fibers from collagen monomers is shown.

Animation:Cartilage and the Chondrocyte
: Formation of collagen fibers from collagen monomers is shown.
 
     
Slide 1: "Normal Hyaline Cartilage from Distance " 400 x 300 pixels 37kb freehand 3dStudio Max Slide 2: "Normal Chondrocyte in its Lacuna " 400 x 300 pxiels 22kb freehand 3dStudio Max
Click Picture or here for larger slides (800 x 500 ) 100kb Click Picture or here for larger slides (800 x 600 ) 63kb

        We will take a close-up look at hyaline cartilage.
         A chondrocyte situated in its lacuna is illustrated. The cell contains organelles for protein synthesis and is capable of secreting a wide variety of molecules, such as cytokines, various enzymes and enzyme inhibitors, growth factors, and matrix components. The chondrocytes are interspersed and fixed within the cartilage matrix.
       As we enter the chondrocyte, we see collagen being synthesized within the cell, and three monomers of Type II collagen form a triple helix resulting in collagen fibrils. The collagen fibrils move outside the cell and form cross-links. The fibrils form collagen fibers, which also have cross-links between each fiber, resulting in structures which have very high tensile strength.

 
     
Slide 3: "Normal Joint Anatomy Knee Cruciate Ligaments " 400 x 300 pixels 24kb Viewpoint Model Worked in 3dStudio Max Slide 4: "Normal Joint Anatomy Knee Menisci " 400 x 300 pixels 23kb Viewpoint Model Worked in 3dStudio Max
Click Picture or here for larger slides (800 x 600 ) 89kb Click Picture or here for larger slides (800 x 600 ) 107kb
     
Slide 5: "Normal Joint Anatomy Knee Cruciate Ligaments " 400 x 300 pixels 24kb Viewpoint Model Worked in 3dStudio Max Slide 6: "Normal Joint Anatomy Knee Cruciate Ligaments " 400 x 300 pixels 24kb Viewpoint Model Worked in 3dStudio Max
Click Picture or here for larger slides (800 x 600 ) 28kb Click Picture or here for larger slides (800 x 600 ) 28kb
 
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